Research, Publications & Media
Women’s Health Researcher, Scientist & Innovator
Advancing women’s health through research, innovation, and scientific discovery. Dr Lana McClements specialises in preeclampsia, pregnancy health, biomarker discovery, biomedical technologies, and healthcare innovation, with more than 100 publications spanning women’s health, cardiovascular disease, cancer, and translational medicine.
Women’s Health Innovation
3D Bioprinted Organoids or Spheroids for Biomarker and Drug Screening
- Matrix directs trophoblast differentiation in a bioprinted organoid model of early placental development | Nature Communications
- 3D printed mini-placentas offer a new way to study pregnancy complications
- Placental organoids for drug and biomarker discovery | Nature Reviews Bioengineering
- 3D in vitro modelling of post-partum cardiovascular health reveals unique characteristics and signatures following hypertensive disorders in pregnancy | Biology of Sex Differences | Springer Nature Link
- Characterisation of cardiac health in the reduced uterine perfusion pressure model and a 3D cardiac spheroid model, of preeclampsia
- CN109952511B – Assay method for determining risk of preeclampsia – Google Patents
- Role of A Novel Angiogenesis FKBPL-CD44 Pathway in Preeclampsia Risk Stratification and Mesenchymal Stem Cell Treatment | The Journal of Clinical Endocrinology & Metabolism | Oxford Academic
- Full article: Targeting oxidative stress in preeclampsia
- The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysis | Biology of Sex Differences | Springer Nature Link
- Maternal plasma proteome profiling of biomarkers and pathogenic mechanisms of early-onset and late-onset preeclampsia | Scientific Reports
- Frontiers | FKBPL and SIRT-1 Are Downregulated by Diabetes in Pregnancy Impacting on Angiogenesis and Endothelial Function
- Overlapping pathogenic signalling pathways and biomarkers in preeclampsia and cardiovascular disease – ScienceDirect
- Angiogenic Imbalance Models of Preeclampsia: From Mechanisms to Clinics | Hypertension
- Frontiers | Mechanisms of Key Innate Immune Cells in Early- and Late-Onset Preeclampsia
- Frontiers | Evaluating oxidative stress targeting treatments in in vitro models of placental stress relevant to preeclampsia
- Liraglutide-Driven Weight Loss Modulates Placental Remodeling in Obese Pregnancies in Mice
- Targeting trophoblast cell mitochondrial dysfunction in preeclampsia via drug repurposing – ScienceDirect
- Non-Viral Gene Delivery Utilizing RALA Modulates sFlt-1 Secretion, Important for Preeclampsia: Nanomedicine: Vol 16, No 22
- Emerging Therapeutic Potential of Mesenchymal Stem/Stromal Cells in Preeclampsia | Current Hypertension Reports | Springer Nature Link
Biomedical Technologies
- A placenta-on-a-chip model to determine the regulation of FKBPL and galectin-3 in preeclampsia | Cellular and Molecular Life Sciences | Springer Nature Link
- CRISPR/Cas9-mediated gene editing in trophoblast cells via mechanoporation for preeclampsia insight | Cell Death & Disease
- The FKBPL-based therapeutic peptide, AD-01, protects the endothelium from hypoxia-induced damage by stabilising hypoxia inducible factor-α and inflammation | Journal of Translational Medicine | Springer Nature Link
- Elucidating the Pathogenesis of Pre-eclampsia Using In Vitro Models of Spiral Uterine Artery Remodelling | Current Hypertension Reports | Springer Nature Link
- FK506 binding protein like, FKBPL, as a novel therapeutic target in 2D and 3D bioprinted, models of cardiac fibrosis – ScienceDirect
- Smart Drug-Delivery System of Upconversion Nanoparticles Coated with Mesoporous Silica for Controlled Release
Healthcare Innovation
- Quantitative Point of Care Tests for Timely Diagnosis of Early‐Onset Preeclampsia with High Sensitivity and Specificity – Masoumeh Ghorbanpour – 2023 – Angewandte Chemie – Wiley Online Library
- Risk of pre‐eclampsia in women taking metformin: a systematic review and meta‐analysis – Alqudah – 2018 – Diabetic Medicine – Wiley Online Library
- Frontiers | Editorial: New Technologies for Women’s Health
- Frontiers | Can Stem Cells Beat COVID-19: Advancing Stem Cells and Extracellular Vesicles Toward Mainstream Medicine for Lung Injuries Associated With SARS-CoV-2 Infections
- Service evaluation of diabetes management during pregnancy in a regional maternity hospital: potential scope for increased self-management and remote patient monitoring through mHealth solutions | BMC Health Services Research | Springer Nature Link
- Evaluation of the diagnostic accuracy of current biomarkers in heart failure with preserved ejection fraction: A systematic review and meta-analysis – ScienceDirect
- Association between Galectin-3 levels within central and peripheral venous blood, and adverse left ventricular remodelling after first acute myocardial infarction | Scientific Reports
- Engaging hard-to-reach populations in research on health in pregnancy: the value of Boal’s simultaneous dramaturgy: Arts & Health: Vol 12, No 1
Cancer, Diabetes and Cardiovascular Disease
- Targeting Treatment-Resistant Breast Cancer Stem Cells with FKBPL and Its Peptide Derivative, AD-01, via the CD44 Pathway | Clinical Cancer Research | American Association for Cancer Research
- The role of sex differences in cardiovascular, metabolic, and immune functions in health and disease: a review for “Sex Differences in Health Awareness Day” | Biology of Sex Differences | Springer Nature Link
- Systemic Loss of FKBPL Uncovers Diabetes-Dependent Pathways of Myocardial and Vascular Injury | Arteriosclerosis, Thrombosis, and Vascular Biology
- The Anti-Migratory Effects of FKBPL and Its Peptide Derivative, AD-01: Regulation of CD44 and the Cytoskeletal Pathway | PLOS One
- FKBPL Is a Critical Antiangiogenic Regulator of Developmental and Pathological Angiogenesis | Arteriosclerosis, Thrombosis, and Vascular Biology
- FKBPL-based peptide, ALM201, targets angiogenesis and cancer stem cells in ovarian cancer | British Journal of Cancer
- FK506-Binding Protein like (FKBPL) Has an Important Role in Heart Failure with Preserved Ejection Fraction Pathogenesis with Potential Diagnostic Utility
- FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4 | BMC Cancer | Springer Nature Link
- Diagnostic and prognostic biomarkers reflective of cardiac remodelling in diabetes mellitus: A scoping review – Chhor – 2023 – Diabetic Medicine – Wiley Online Library
- E-Cigarette Aerosol Condensate Leads to Impaired Coronary Endothelial Cell Health and Restricted Angiogenesis
- In Vitro Evaluation of A Hybrid Drug-Delivery Nanosystem for Fibrosis Prevention In Cell Therapy for Type 1 Diabetes: Nanomedicine: Vol 18, No 1
- Systemic Biomarkers and Unique Pathways in Different Phenotypes of Heart Failure with Preserved Ejection Fraction
- FKBPL is associated with metabolic parameters and is a novel determinant of cardiovascular disease | Scientific Reports
Frequently Asked Questions
Find answers to common questions about Dr. Lana McClements’ research, publications, and media.
Lana's research focuses on women's health, pregnancy complications such as preeclampsia, cardiovascular disease, biomarker discovery, diagnostics, healthcare innovation, and emerging biomedical technologies that improve patient outcomes.
Lana has contributed extensively to preeclampsia research through biomarker discovery, diagnostic development, drug repurposing, and innovative technologies designed to improve early detection, risk assessment, and treatment strategies for pregnancy-related complications.
Lana's work bridges scientific discovery and real-world healthcare applications through translational research, biomedical technologies, diagnostics, point-of-care testing, and the commercialisation of innovative healthcare solutions.
Lana has contributed to the development of advanced biomedical technologies including 3D bioprinted placental organoids, placenta-on-a-chip models, diagnostic platforms, nanotechnology-based drug delivery systems, and gene-editing applications for women's health research.
Yes. Lana has authored and co-authored more than 100 publications, including peer-reviewed journal articles, conference proceedings, editorials, expert opinions, patent applications, and research contributions published in leading international scientific journals.
Trusted by Global Media, Biotech & Academic Leaders
Dr. Lana McClements’ pioneering work in women’s health and biomedical innovation is recognized by leading international media, top-tier universities, and global biotechnology organizations.
Advancing Women's Health Through Research & Innovation
From biomarker discovery and biomedical technologies to healthcare innovation and research translation, Lana is passionate about transforming scientific discoveries into real-world solutions that improve women’s health outcomes.